Aplastic anemia is a rare condition in which your body stops producing enough new blood cells. This condition leaves you fatigued and more prone to infections and uncontrolled bleeding. A serious condition, aplastic anemia can develop in any age. Aplastic anemia symptoms can affect people differently . They may come on slowly or suddenly. Some people may have manageable , mild symptoms. But others may have symptoms that indicate severe aplastic anemia (SAA). Severe aplastic anemia requires urgent medical treatment.
Thanks to Bone Marrow Transplant is the only curative option in Severe aplastic anemia.
Bone marrow transplantation (BMT) or Hematopoietic stem cell transplant is a non-surgical procedure that infuses healthy cells into the body. It is used to treat blood disorders like Aplastic anaemia , Sickle cell anaemia and Thalassemia . In the procedure, healthy stem cells taken from the bone marrow , blood, or umbilical cord are used to replace cancerous or faulty blood cells. The stem cell transplant can be of three types - Autologous (Self-donate stem cells), Allogeneic (Matched / stem cells from a donor), or Syngeneic (Only possible for identical twins).
Procedure Needed : Allogeneic Bone Marrow (Stem Cell) Transplant.
Allogeneic bone marrow or stem cell transplant (Matched / stem cells from a donor). Allogeneic Bone Marrow Transplant (BMT) is typically recommended to treat certain medical conditions where the bone marrow is dysfunctional.
To look for options for allogenic bone marrow transplant HLA typing of patient and sibling should be performed.
If there is any sibling they should be tested for HLA typing. HLA typing of parents can be done as some time we are getting full match with parents. In case of non-availability of familial donor unrelated matched donor may be considered.
If this procedure is performed with half-matched stem cells, it is called haploidentical bone marrow transplant . Careful preparation is required for successful results, which include a conditioning for patients with Aplastic anemia . It might take up to several weeks for healthy , cells to grow after the bone marrow transplant procedure.
Most Important Pre-requisite: Stem cell donor (It could be HLA matched sibling/ Parents: HLA typing of patient and sibling/ Parents is needed to identify suitable donor).
APLASTIC ANEMIA
MRD (Minimal residual disease)- 26000-30000 USD- 28 days hospital stay- 80% Success (immediate).
HAPLO- 35000-45000 USD- 45 days hospital stay- 60% Success (immediate)
MUD (Matched unrelated donor)- 26000-30000 USD+Registry fee- 35 days hospital stay- 70% Success (immediate).
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