Allogeneic bone marrow or stem cell transplant (Matched / stem cells from a donor). Allogeneic Bone Marrow Transplant (BMT) is typically recommended to treat certain medical conditions where the bone marrow is dysfunctional.
. Cancers like leukaemia, Myelo-dysplasia etc.
. Disease that affect the production of bone marrow cells like
. Aplastic anaemia (acquired or inherited)
. Other marrow failure states (ex. Congenital neutropenia, amega karyocytic thrombocyto-penia etc)
. Severe immunodeficiency syndrome's
. Sickle cell anaemia
. Thalassemia major
To look for options for allogenic bone marrow transplant HLA typing of patient and sibling should be performed.
If there is any sibling they should be tested for HLA typing. HLA typing of parents can be done as some time we are getting full match with parents. In case of non-availability of familial donor unrelated matched donor may be considered.
If this procedure is performed with half-matched stem cells, it is called haploidentical bone marrow transplant . Careful preparation is required for successful results, which include a conditioning for patients with cancer. It might take up to several weeks for healthy , cancer-free cells to grow after the bone marrow transplant procedure.
Most Important Pre-requisite: Stem cell donor (It could be HLA matched sibling/ Parents: HLA typing of patient and sibling/ Parents is needed to identify suitable donor).
a. APLASTIC ANEMIA
MRD (Minimal residual disease)- 28000 USD- 28 days hospital stay- 80% Success (immediate).
HAPLO- 35000-40000 USD- 40 days hospital stay- 80% Success (immediate)
MUD (Matched unrelated donor)- 28000 USD+Registry fee- 30 days hospital stay- 70% Success (immediate).
b. ACUTE LEUKAEMIA
MRD (Minimal residual disease)- 26000 USD- 28 days hospital stay- 80% Success (immediate).
HAPLO- 35000-40000 USD- 40 days hospital stay- 80% Success (immediate)
MUD (Matched unrelated donor)- 28000 USD+Registry fee- 30 days hospital stay- 70% Success (immediate).
c. THALASSEMIA/SICKLE CELL ANEMIA
MRD (Minimal residual disease)- 30000 USD- 28 days hospital stay- 80% Success (immediate).
HAPLO- 40000-45000 USD- 45 days hospital stay- 60% Success (immediate)
MUD (Matched unrelated donor)- 30000 USD+Registry fee- 35 days hospital stay- 70% Success (immediate).
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